Sheet1
sheet 1:point of care testing for four creatinine devices
device/criteria ABL Flex 800 StatSensor Piccolo Reflotron
manufacturer Radiometer Abbott POC Roche Roche
sample type Whole blood (A,V,C) Whole blood (A,V,C) Whole blood, serum or plasma Whole blood (V,C) or serum, plasma
sample volume(ul) 125 (c)/250 (syr) ?L 1 ?L 9 ?L 30?L
Measuring Range 10–2000 ?M 27–1056 ?M 18–1768 ?M 45–884 ?M
Size, Weight Benchtop, 33 kg Hand held, 0.4 kg Benchtop, 5 kg Benchtop, 5 kg
time range(minutes) 1 0.5 8.5 , then 0.6 2
measing range 10–2000 ?M 27–1056 ?M 18–1768 ?M 45–884 ?M
Power AC AC or battery AC AC
Connectivity yes yes yes yes
Calculation of eGFR Yes Yes No Yes
Consumable Sensor Cassette Dry strip Rotor Dry strip
Calibration reference IDMS via HPLC Not available SRM 967 Not available
Method Principle Enzymatic with amp biosensor Enzymatic with amp biosensor Enzymatic with indicator absorbance Enzymatic with dye reflectance
More Analytes Elu, Bgas, metabs Nil Elu, metabs, lipids, enzymes Elu, Hb, metabs, lipids, enzymes
Reference:
1.Galambos C, B. D. R. D. C. H. C. M., 2000. . False-Positive Plasma Troponin I with the AxSYM Analyzer. s.l.:Clinical Chemistry .
2.RC, H., 2003. Hemolysis Interference in the Ortho-Clinical Diagnostics Vitros ECi cTnI Assay. s.l.:Clinical Chemistry .
3.Schenk PW, C. K. W. E. d. R. D., 2007. Point-of-care creatinine testing in children at risk for sudden deterioration of renal function.. s.l.:Clinical Chemistry & Laboratory Medicine..
http://www.amsl.com.au/site/cms/point-of-carehttp://www.bio-rad.com/evportal/evolutionPortal.portal?_http://www.bio-rad.com/webroot/web/pdf/cdg/literature/A244_Diabetes.pdfhttp://www.captodayonline.com/productguides/http://www.ekfdiagnostics.com/QuoLab_713.aspxhttp://www.google.com.au/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&cad=rja&ved=0CD8QFjAD&url=http%3A%2F%2Fwww.ekfdiagnostics.de%2Fsystem%2Fresources%2Finterfaces%2FContentDocument.ashx%3Fid%3D148&ei=2V9aUvzEKYSViQf_k4BY&usg=AFQjCNEZP4_gJya8UtsqYLcwvkwSgJwUGw&bvm=bv.53899372,d.aGchttp://www.hemocue.com/index.php?page=1207&no_rewrite=1&sok=201http://www.hemocue.com/international/Products/Data_Management/201_DM_Specifications-1230.html
Sheet2
SHEET 2:Point-of-Care Troponin Devices
Device/criteria i-STAT (cTnI) Cardio3 (cTnI) LifeSign MI Troponin I ZAP Troponin I
Cardio2 LifeSign MI Myoglobin/Troponin I ZAP Troponin I/Myoglobi
Triage Troponin I LifeSign MI CK-MB/Myoglobin/Troponin I
It is normally used in a platform(MeterPro) Capillary, Venous, Arterial, Neonate
Manufacturer Abbott Alere LifeSign/Princeton BioMeditech Corp. ZBx Corporation/Innova
99th Percentile, mcg/L 80 (16.5) Cardio3: 0.022 (17) NR NR
(% CV)
Chemistry PSD GDH GOx GD
Test time 10 15 25 45
Test range 2 – 30 mmol/L 2 – 20 mmol/L 2 – 20 mmol/L 3-30 mmol/L
Individual strip package Yes Yes Yes Yes
Temperature (oC) 20-40 25-60 15 – 40 15-55
Humidity (%) 20-80 20-80 10 – 90 30-45
Interferences Galactose > 25mg/dL, ascorbic acid > 4 mg/dL high level of billirubin, ascorbic acid,triglycerides
acetaminophan, ascorbic acid, dopamine, ephedra, D(+)Galactose, ibuprrfen, L-Dopa, Exhibit no interfeference
Calibration reference Manufacturer IFC IFC
Accuracy 99.5% samples within minimun acceptable performance Capillary results <75 mg/dL 100% within ±15 mg/dL, >75 mg/dL 97% within ±20% Glucose concentrations <75 mg/dL 100% adult ICU arterial and venous results ±15 mg/dL <75 mg/dL 100% adult ICU arterial and venous results ±20% criteria, Glucose <75 mg/dL 100% within ±15 mg/dL, glucose Total 97% within ±20%, Venous results 99% within ±20%, Arterial 97% within ± ?75 mg/dL 99.4% within ±20% 20%, Neonatal 96% within ±20% Quality Control Recommendation Need to run control every month Need to run control every batch Not available Not available References 1. society, A., 2015. articles. Online Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100277/ Accessed 2016 September 2016. 2. RC, H., 2003. Hemolysis Interference in the Ortho-Clinical Diagnostics Vitros ECi cTnI Assay. s.l.:Clinical Chemistry .
